Mechanisms of nutritional and hormonal regulation of lipogenesis

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Mechanisms of nutritional and hormonal regulation of lipogenesis.

Fat build-up is determined by the balance between lipogenesis and lipolysis/fatty acid oxidation. In the past few years, our understanding of the nutritional, hormonal and particularly transcriptional regulation of lipogenesis has expanded greatly. Lipogenesis is stimulated by a high carbohydrate diet, whereas it is inhibited by polyunsaturated fatty acids and by fasting. These effects are part...

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Nutritional and hormonal regulation of genes for lipogenic enzymes.

The de novo synthesis of long-chain fatty acids, a process that occurs primarily in liver in many species, is high in animals fed on diets with a high content of carbohydrate, and low in starved animals. The activities of the ‘lipogenic’ set of hepatic enzymes follow the same pattern. Two members of this lipogenic set are cytosolic malic enzyme (EC 1.1.1.40), which furnishes most of the NADPH f...

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ژورنال

عنوان ژورنال: EMBO reports

سال: 2001

ISSN: 1469-221X,1469-3178

DOI: 10.1093/embo-reports/kve071